Adrenal Virilism: Abnormal Response to ACTH

Congenital Adrenal Cortical Insufficiency with Virilism

This paper presents the case of a boy developing symptoms of adrenal insufficiency soon after birth, followed by unmistakable evidences of the changes in the development associated with androgens. Other reports bring out the fact that the picture of increased androgenic activity with or without adrenocortical insufficiency is associated with hyperplasia and persistence of the fetal (androgenic)...

Agouti yellow mutation increases adrenal response to ACTH in mice.

OBJECTIVE Agouti protein (AP) and agouti-related protein with a similar sequence and action are endogenous antagonists of melanocortin receptors, implicated in the control of the hypothalamo-pituitary-adrenal (HPA) axis. Dominant mutation of the agouti gene (agouti yellow (A(y))) in heterozygous A(y)/a mice leads to ectopic overexpression of AP and produces an obese phenotype. The existing data...

Nycthemeral rhythm in adrenal responsiveness to ACTH.

Adrenal adenosine 3',5'-cyclic monophosphate (cAMP) and corticosterone responses to exogenous ACTH were found to be about 2.5 times greater in the evening (at lights off) than in the morning (at lights on) in rats. The rhythm in adrenal responsiveness to ACTH was found to persist in rats treated with dexamethasone 15 and 3 h before exogenous ACTH (in the presumed absence of a rhythm in endogeno...

Adrenal Cortical Hyperplasia with Virilism: Diagnosis, Course and Treatment.

ACTH-independent macronodular adrenal hyperplasia.

Adrenocorticotropic hormone- (ACTH-)independent macronodular adrenal hyperplasia (AIMAH) is an infrequent cause of Cushing's syndrome (CS). AIMAH presents as incidental radiological finding or with subclinical or overt CS, occasionally with secretion of mineralocorticoids or sex steroids. The pathophysiology of this entity is heterogeneous. The aberrant adrenal expression and function of one or...